With Alberto Gonzales now gone, Karl Rove gone, and most of the others who came to Washington with Bush also gone (e.g., Harriet Myers, Donald Rumsfeld, Daniel Bartlett, and Andrew Card, to name a few), who is going to continue to tell President Bush what he wants to hear?
Both in his public speeches and in published accounts of more private conversations (such as are recounted in Woodward's State of Denial), the President consistently presents himself as locked into his view of reality, indifferent to facts contradicting those views, and unappreciative of those who wish to present those adverse facts and alternate views.
George W. Bush has spent most of his career cultivating a dependable stable of sycophants and replacing them now may be difficult because, believe it or not, a successful career in politics and government service usually requires having some independent judgment. So, finding people who are (a) qualified, (b) willing to mindlessly support the President's tunnel visions, (c) likely to be confirmed by the Senate, is not going to be easy.
So Bush is going to have to begin dealing with bad news and conflicting views from new appointees within his administration. Either that, or he will further isolate himself from real political issues and make himself even more irrelevant than the usual lame duck President.
My guess is that it will be the latter, and I simply hope he doesn't hurt more people (such as American troops in Iraq) than he really needs to while he remains fixated in his righteousness.